Human Topoisomerase IIα Molecular Modeling Repository (HTopo2MMR)

HT2MMR00012


HT2MMR00012.png

This structure represents the homology modeled C-closed conformation of enzyme human topoisomerase IIalpha (hTopoIIalpha), complexed with DNA. The structural domains which are modeled in this structure are the central domain and C-terminal domain. In this structure, the DNA is in its uncleaved state. This conformation represents the hTopoIIalpha-DNA complex before the DNA-cleavage step.



Downloads




     
  



Back