Human Topoisomerase IIα Molecular Modeling Repository (HTopo2MMR)

HT2MMR00009


HT2MMR00009.png

This structure is the complex of human Topoisomerase IIalpha (hTopoIIalpha) ATPase domain with adenylyl-imidodiphosphate (AMP-PNP or ANP) molecules at each of the ATP-binding sites and ICRF-187 (also known as dexrazoxane) at the ICRF-binding site. ICRF-187 is reported as the hTopoIIalpha mediated ATP-hydrolysis inhibitor. It binds at the interface of the two N-terminal domains. The molecule ANP acts as ATP-competitive inhibitor of hTopoIIalpha.



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