This structure is the complex of human Topoisomerase IIalpha (hTopoIIalpha) ATPase domain with ADP molecule at one ATP-binding site, ATP molecule at other ATP-binding site and ICRF-187 (also known as dexrazoxane) at the ICRF-binding site. ICRF-187 is reported as the hTopoIIalpha mediated ATP-hydrolysis inhibitor. It binds at the interface of the two N-terminal domains. This structure can be used to demonstrate the effect of nucleotide-binding on the molecular recognition interaction of ICRF-187 and subsequent differences in the intersubunit interactions.